Bengt Sennblad NBIS expert

omics integration, reproducible research, probabilistic modeling, algorithmics, genetic interactions, genetic associations studies, genome evolution

Bengt has PhD in Biology from Uppsala University and a Associate professorship (‘Docentur’) in Computer Science at the Royal Institute of Technology, KTH. During his time as Assistant professor at the Stockholm Bioinformatics Center (SBC), he initiated an ongoing collaborative project aimed at modeling genome evolution; this resulted in the first probabilistic gene evolution model integrating gene duplication and loss, lateral transfer and sequence evolution. He has also worked in the field of medical genetics of complex diseases at Karolinska Institutet, developing statistical methods for studying interactions in genome-wide association studies and providing bioinformatics expertise to local projects, as well as internationl consortia aimed at cardiovascular disease studies. Bengt joined the NBIS long-term support facility in 2015. His research interest includes in methods for integrated analysis of data from several different omics sources, reproducible research, genetics analysis, genomic evolution and method development.

Selected publications

Iotchkova, V., Huang, J., Morris, J. A., (…28 authors …), Sennblad, B., and (36 further authors) (2016) Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. Nat. Genet.

Frånberg, M., Gertow, K., Hamsten, A., (…2 authors …), and Sennblad, B. (2015) Discovering Genetic Interactions in Large-Scale Association Studies by Stage-wise Likelihood Ratio Tests. PLoS Genetics , 11 , e1005502.

Joshi, P. K., Esko, T., Mattsson, H., (…211 authors …), Sennblad, B., and (15 further authors) (2015) Directional dominance on stature and cognition in diverse human populations. Nature , 523 , 459–462.

Mahmudi, O., Sennblad, B., and (3 further authors) (2015) Gene-pseudogene evolution: a probabilistic approach. BMC Genomics , 16 Suppl 10 , S12.

Swerdlow, D. I., Preiss, D., Kuchenbaecker, K. B., (…40 authors …), Sennblad, B., and (92 further authors) (2015) HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet , 385 , 351–361.

Sjöstrand, J., Tofigh, A., Daubin, V., (…1 authors …), Sennblad, B., and (1 further authors) (2014) A Bayesian Method for Analyzing Lateral Gene Transfer. Systematic Biology , 63 , 409–420.

Gertow, K., Sennblad, B., and (60 further authors) (2012) Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk. Circ. Cardiovasc. Genet. , 5 , 656–665.

Linder, M., Britton, T., and Sennblad, B. (2011) Evaluation of Bayesian models of substitution rate evolution–parental guidance versus mutual independence. Systematic Biology , 60 , 329–342.

Sennblad, B., Lagergren, J., and (-1 further authors) (2009) Probabilistic orthology analysis. Systematic Biology , 58 , 411–424.

Arvestad, L., Lagergren, J., and Sennblad, B. (2009) The gene evolution model and computing its associated probabilities. J. ACM , 56 , 1–44.

Bengt Sennblad NBIS expert

omics integration, reproducible research, probabilistic modeling, algorithmics, genetic interactions, genetic associations studies, genome evolution

Bengt has PhD in Biology from Uppsala University and a Associate professorship (‘Docentur’) in Computer Science at the Royal Institute of Technology, KTH. During his time as Assistant professor at the Stockholm Bioinformatics Center (SBC), he initiated an ongoing collaborative project aimed at modeling genome evolution; this resulted in the first probabilistic gene evolution model integrating gene duplication and loss, lateral transfer and sequence evolution. He has also worked in the field of medical genetics of complex diseases at Karolinska Institutet, developing statistical methods for studying interactions in genome-wide association studies and providing bioinformatics expertise to local projects, as well as internationl consortia aimed at cardiovascular disease studies. Bengt joined the NBIS long-term support facility in 2015. His research interest includes in methods for integrated analysis of data from several different omics sources, reproducible research, genetics analysis, genomic evolution and method development.

Selected publications

Iotchkova, V., Huang, J., Morris, J. A., (…28 authors …), Sennblad, B., and (36 further authors) (2016) Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. Nat. Genet.

Frånberg, M., Gertow, K., Hamsten, A., (…2 authors …), and Sennblad, B. (2015) Discovering Genetic Interactions in Large-Scale Association Studies by Stage-wise Likelihood Ratio Tests. PLoS Genetics , 11 , e1005502.

Joshi, P. K., Esko, T., Mattsson, H., (…211 authors …), Sennblad, B., and (15 further authors) (2015) Directional dominance on stature and cognition in diverse human populations. Nature , 523 , 459–462.

Mahmudi, O., Sennblad, B., and (3 further authors) (2015) Gene-pseudogene evolution: a probabilistic approach. BMC Genomics , 16 Suppl 10 , S12.

Swerdlow, D. I., Preiss, D., Kuchenbaecker, K. B., (…40 authors …), Sennblad, B., and (92 further authors) (2015) HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet , 385 , 351–361.

Sjöstrand, J., Tofigh, A., Daubin, V., (…1 authors …), Sennblad, B., and (1 further authors) (2014) A Bayesian Method for Analyzing Lateral Gene Transfer. Systematic Biology , 63 , 409–420.

Gertow, K., Sennblad, B., and (60 further authors) (2012) Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk. Circ. Cardiovasc. Genet. , 5 , 656–665.

Linder, M., Britton, T., and Sennblad, B. (2011) Evaluation of Bayesian models of substitution rate evolution–parental guidance versus mutual independence. Systematic Biology , 60 , 329–342.

Sennblad, B., Lagergren, J., and (-1 further authors) (2009) Probabilistic orthology analysis. Systematic Biology , 58 , 411–424.

Arvestad, L., Lagergren, J., and Sennblad, B. (2009) The gene evolution model and computing its associated probabilities. J. ACM , 56 , 1–44.